Detailed view for LmjF.28.1490

Basic information

TDR Targets ID: 23795
Leishmania major, hypothetical protein, conserved
Source Database / ID:  TriTrypDB  GeneDB

pI: 10.0692 | Length (AA): 138 | MW (Da): 14454 | Paralog Number: 2

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 4

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF04241   Protein of unknown function (DUF423)

Gene Ontology

Mouse over links to read term descriptions.
No GO information for this protein.

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

No model available for this protein in Modbase.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Upper 80-100% percentile amastigotes, metacyclic. Fernandes MC
Show/Hide expression data references
  • Fernandes MC Dual Transcriptome Profiling of Leishmania-Infected Human Macrophages Reveals Distinct Reprogramming Signatures.

Orthologs

Ortholog group members (OG5_128471)

Species Accession Gene Product
Arabidopsis thaliana AT2G04900   hypothetical protein
Brugia malayi Bm1_27850   CG4686-PA
Caenorhabditis elegans CELE_Y106G6H.8   Protein Y106G6H.8
Dictyostelium discoideum DDB_G0269766   hypothetical protein
Dictyostelium discoideum DDB_G0270942   hypothetical protein
Drosophila melanogaster Dmel_CG4686   CG4686 gene product from transcript CG4686-RA
Drosophila melanogaster Dmel_CG42395   CG42395 gene product from transcript CG42395-RD
Escherichia coli b2807   UPF0382 family inner membrane protein
Echinococcus granulosus EgrG_000188800   protein of unknown function DUF423
Echinococcus multilocularis EmuJ_000188800   protein of unknown function DUF423
Homo sapiens ENSG00000205544   transmembrane protein 256
Leishmania braziliensis LbrM.28.1670   hypothetical protein, conserved
Leishmania braziliensis LbrM.28.1650   hypothetical protein, conserved
Leishmania braziliensis LbrM.28.1660   hypothetical protein, conserved
Leishmania donovani LdBPK_281620.1   Protein of unknown function (DUF423), putative
Leishmania donovani LdBPK_281610.1   Protein of unknown function (DUF423), putative
Leishmania donovani LdBPK_281630.1   Protein of unknown function (DUF423), putative
Leishmania infantum LinJ.28.1610   hypothetical protein, conserved
Leishmania infantum LinJ.28.1630   hypothetical protein, conserved
Leishmania infantum LinJ.28.1620   hypothetical protein, conserved
Leishmania major LmjF.28.1510   hypothetical protein, conserved
Leishmania major LmjF.28.1500   hypothetical protein, conserved
Leishmania major LmjF.28.1490   hypothetical protein, conserved
Leishmania mexicana LmxM.28.1490   hypothetical protein, conserved
Leishmania mexicana LmxM.28.1510   hypothetical protein, conserved
Leishmania mexicana LmxM.28.1500   hypothetical protein, conserved
Loa Loa (eye worm) LOAG_02131   hypothetical protein
Mus musculus ENSMUSG00000070394   transmembrane protein 256
Oryza sativa 4334128   Os03g0751000
Onchocerca volvulus OVOC3420  
Schistosoma japonicum Sjp_0209660   similar to UPF0451 protein C17orf61 homolog precursor, putative
Schistosoma mansoni Smp_096290.2   hypothetical protein
Schistosoma mansoni Smp_096290.1   hypothetical protein
Trypanosoma brucei gambiense Tbg972.11.8680   hypothetical protein, conserved
Trypanosoma brucei gambiense Tbg972.11.9770   hypothetical protein, conserved
Trypanosoma brucei Tb927.11.7490   Protein of unknown function (DUF423), putative
Trypanosoma brucei Tb927.11.7500   Protein of unknown function (DUF423), putative
Trypanosoma brucei Tb927.11.8740   Protein of unknown function (DUF423), putative
Trypanosoma cruzi TcCLB.511207.10   hypothetical protein, conserved
Trypanosoma cruzi TcCLB.508823.10   hypothetical protein, conserved
Trypanosoma cruzi TcCLB.462761.16   Protein of unknown function (DUF423), putative
Trypanosoma cruzi TcCLB.508823.20   hypothetical protein, conserved
Trypanosoma cruzi TcCLB.511201.49   Protein of unknown function (DUF423), putative

Essentiality

LmjF.28.1490 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb11.02.5480 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb11.02.5480 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (6 days) alsford
Tb11.02.5480 Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb11.02.5480 Trypanosoma brucei significant gain of fitness in differentiation of procyclic to bloodstream forms alsford
Tb11.12.0008 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb11.12.0008 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (6 days) alsford
Tb11.12.0008 Trypanosoma brucei significant loss of fitness in procyclic forms alsford
Tb11.12.0008 Trypanosoma brucei significant loss of fitness in differentiation of procyclic to bloodstream forms alsford
b2807 Escherichia coli non-essential goodall
CELE_Y106G6H.8 Caenorhabditis elegans slow growth wormbase
Show/Hide essentiality data references
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Druggability index (range: 0 to 1): 0.1

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier LmjF.28.1490 (Leishmania major), hypothetical protein, conserved
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